• InverseParallax@lemmy.world
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    7 hours ago

    First pass metabolism, or just absorbed by mucous membranes of the mouth, blood flow isn’t great so absorption is less systemic, just mess up your mouth and throat a bit really, but might help some symptoms locally.

    The nasal dose is low compared to oral and those dissolve in areas with high blood uptake.

  • philpo@feddit.org
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    23 hours ago

    They get destroyed by stomach acids and saliva enzymes. Unlikely to even make it towards First pass.