• sinceasdf@lemmy.world
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    4 months ago

    I think there is likely to still be just as large of a personal variance in the rate that lisdexamphetamine is cleaved into the active metabolite, so the same problem arises.

    I think anything that delays the active metabolite from taking effect technically dampens the addictive potential; the longer the better. I also think it’s unlikely to really solve the problem though tbh. People can still tell what’s causing how they feel when they start a new medication.

    • cheese_greater@lemmy.world
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      4 months ago

      You’re never gonna fully attnuate all the edge cases and it doesn’t really matter that some people end up being “allergic” or oversensitive or undersensitive to it. Thats what titration and medical supervision are for, not everything works for everyone.

      Thats why choice and second/third/fourth line etc treatments exist. I sometimes do wonder if you did a double blind with folks and didn’t tell them, I would conjecture the hyper-extended nature of such things if that were so established could be sufficient to mitigate for individual differences in metabolic-polymorphism or whatever